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1

MEKK2 mediates an alternative β-catenin pathway that promotes bone formation

Greenblatt, Matthew Blake, Shin, Dong Yeon, Oh, Hwanhee, Lee, Ki-Young, Zhai, Bo, Gygi, Steven P., Lotinun, Sutada, Baron, Roland, Liu, Dou, Su, Bing, Glimcher, Laurie H., Shim, Jae-Hyuck

Journal:

Proceedings of the National Academy of Sciences

Year:

2016

Language:

english

File:

PDF, 1.70 MB

english, 2016

2

Bone Loss in Rheumatoid Arthritis: Basic Mechanisms and Clinical Implications

Shim, Jae-hyuck, Stavre, Zheni, Gravallese, Ellen M.

Journal:

Calcified Tissue International

Year:

2017

Language:

english

File:

PDF, 1.16 MB

english, 2017

3

Qualitative and quantitative differences in the intensity of Fas-mediated intracellular signals determine life and death in T cells

Min-Jung Shin, Jae-Hyuck Shim, Jae-Young Lee, Wook-Jin Chae, Heung-Kyu Lee, Tomohiro Morio, Jun Han Park, Eun-Ju Chang, Sang-Kyou Lee

Journal:

International Journal of Hematology

Year:

2010

Language:

english

File:

PDF, 434 KB

english, 2010

4

TAK1 mediates BMP signaling in cartilage

Matthew B. Greenblatt, Jae-Hyuck Shim, Laurie H. Glimcher

Journal:

Annals of the New York Academy of Sciences

Year:

2010

Language:

english

File:

PDF, 396 KB

english, 2010

5

TAK1 is an essential regulator of BMP signalling in cartilage

Shim, Jae-Hyuck, Greenblatt, Matthew B, Xie, Min, Schneider, Michael D, Zou, Weiguo, Zhai, Bo, Gygi, Steven, Glimcher, Laurie H

Journal:

The EMBO Journal

Year:

2009

Language:

english

File:

PDF, 1.86 MB

english, 2009

6

The E3 ubiquitin ligase Wwp2 regulates craniofacial development through mono-ubiquitylation of Goosecoid

Huang, Zhiwei, Brady, Nicholas, Hu, Dorothy, Drapp, Rebecca, Sigrist, Kirsten, Glimcher, Laurie H., Jones, Dallas, Zou, Weiguo, Chen, Xi, Shim, Jae-Hyuck

Journal:

Nature Cell Biology

Year:

2010

Language:

english

File:

PDF, 1.58 MB

english, 2010

7

T-bet represses TH17 differentiation by preventing Runx1-mediated activation of the gene encoding RORγt

Lazarevic, Vanja, Chen, Xi, Shim, Jae-Hyuck, Hwang, Eun-Sook, Jang, Eunjung, Bolm, Alexandra N, Oukka, Mohamed, Kuchroo, Vijay K, Glimcher, Laurie H

Journal:

Nature Immunology

Year:

2010

Language:

english

File:

PDF, 1.06 MB

english, 2010

8

Mitogen-Activated Protein Kinase Pathways in Osteoblasts

Greenblatt, Matthew B., Shim, Jae-Hyuck, Glimcher, Laurie H.

Journal:

Annual Review of Cell and Developmental Biology

Year:

2013

Language:

english

File:

PDF, 391 KB

english, 2013

9

Amelioration of neurodegenerative diseases by cell death-induced cytoplasmic delivery of humanin

Park, Tae-Yoon, Kim, Seung-Hyung, Shin, Yoon-Chul, Lee, Nae-Hyun, Lee, Rae-Kyung Christina, Shim, Jae-Hyuck, Glimcher, Laurie H., Mook-Jung, Inhee, Cheong, Eunji, Kim, Won-Ki, Honda, Fumiko, Morio, To

Journal:

Journal of Controlled Release

Year:

2013

Language:

english

File:

PDF, 1.10 MB

english, 2013

10

CHMP5 Is Essential for Late Endosome Function and down-Regulation of Receptor Signaling during Mouse Embryogenesis

Jae-Hyuck Shim, Changchun Xiao, Matthew S. Hayden, Ki-Young Lee, E. Sergio Trombetta, Marc Pypaert, Atsuki Nara, Tamotsu Yoshimori, Bettina Wilm, Hediye Erdjument-Bromage, Paul Tempst, Brigid L. M. Ho

Journal:

The Journal of Cell Biology

Year:

2006

Language:

english

File:

PDF, 2.54 MB

english, 2006

11

Salt-Inducible Kinases 1 and 3 Negatively Regulate Toll-Like Receptor 4-Mediated Signal

Yong Kim, So, Jeong, Sookyung, Chah, Kyong-Hwa, Jung, Eunyu, Baek, Kwan-Hyuck, Kim, Seong-Tae, Shim, Jae-Hyuck, Chun, Eunyoung, Lee, Ki-Young

Journal:

Molecular Endocrinology

Year:

2013

Language:

english

File:

PDF, 2.08 MB

english, 2013

12

Schnurri-3 regulates ERK downstream of WNT signaling in osteoblasts

Shim, Jae-Hyuck, Greenblatt, Matthew B., Zou, Weiguo, Huang, Zhiwei, Wein, Marc N., Brady, Nicholas, Hu, Dorothy, Charron, Jean, Brodkin, Heather R., Petsko, Gregory A., Zaller, Dennis, Zhai, Bo, Gygi

Journal:

Journal of Clinical Investigation

Year:

2013

Language:

english

File:

PDF, 3.46 MB

english, 2013

13

Phosphoinositide-dependent kinase-1 inhibits TRAF6 ubiquitination by interrupting the formation of TAK1–TAB2 complex in TLR4 signaling

Moon, Gyuyoung, Kim, Juhong, Min, Yoon, Wi, Sae Mi, Shim, Jae-Hyuck, Chun, Eunyoung, Lee, Ki-Young

Journal:

Cellular Signalling

Year:

2015

Language:

english

File:

PDF, 2.63 MB

english, 2015

14

Roles for TAB1 in regulating the IL-1-dependent phosphorylation of the TAB3 regulatory subunit and activity of the TAK1 complex

Mendoza, Heidi, Campbell, David G., Burness, Kerry, Hastie, James, Ronkina, Natalia, Shim, Jae-Hyuck, Arthur, J. Simon C., Davis, Roger J., Gaestel, Matthias, Johnson, Gary L., Ghosh, Sankar, Cohen, P

Journal:

Biochemical Journal

Year:

2008

Language:

english

File:

PDF, 791 KB

english, 2008

15

Cereblon negatively regulates TLR4 signaling through the attenuation of ubiquitination of TRAF6

Min, Yoon, Wi, Sae Mi, Kang, Jung-Ah, Yang, Taewoo, Park, Chul-Seung, Park, Sung-Gyoo, Chung, Sungkwon, Shim, Jae-Hyuck, Chun, Eunyoung, Lee, Ki-Young

Journal:

Cell Death and Disease

Year:

2016

Language:

english

File:

PDF, 2.55 MB

english, 2016

16

Zinc inhibits osteoclast differentiation by suppression of Ca2+-Calcineurin-NFATc1 signaling pathway

Park, Kwang, Park, Boryung, Yoon, Dong, Kwon, Seung-Hyun, Shin, Dong, Lee, Jin, Lee, Hyun, Shim, Jae-Hyuck, Park, Jeon, Lee, Jae

Journal:

Cell Communication and Signaling

Year:

2013

Language:

english

File:

PDF, 3.34 MB

english, 2013

17

Post-translational control of T cell development by the ESCRT protein CHMP5

Adoro, Stanley, Park, Kwang Hwan, Bettigole, Sarah E, Lis, Raphael, Shin, Hee Rae, Seo, Heewon, Kim, Ju Han, Knobeloch, Klaus-Peter, Shim, Jae-Hyuck, Glimcher, Laurie H

Journal:

Nature Immunology

Year:

2017

Language:

english

File:

PDF, 4.48 MB

english, 2017

18

c-Jun N-terminal kinases (JNKs) are critical mediators of osteoblast activity in vivo

Xu, Ren, Zhang, Chao, Shin, Dong Yeon, Kim, Jung-Min, Lalani, Sarfaraz, Li, Na, Yang, Yeon-Suk, Liu, Yifang, Eiseman, Mark, Davis, Roger J., Shim, Jae-Hyuck, Greenblatt, Matthew B.

Journal:

Journal of Bone and Mineral Research

Year:

2017

Language:

english

File:

PDF, 1.08 MB

english, 2017

19

A cell surface clicked navigation system to direct specific bone targeting

Kim, Young, Zhang, Zhe, Shim, Jae-Hyuck, Lee, Tae Sup, Tung, Ching-Hsuan

Journal:

Bioorganic & Medicinal Chemistry

Year:

2017

Language:

english

File:

PDF, 950 KB

english, 2017

20

Discovery of a periosteal stem cell mediating intramembranous bone formation

Debnath, Shawon, Yallowitz, Alisha R., McCormick, Jason, Lalani, Sarfaraz, Zhang, Tuo, Xu, Ren, Li, Na, Liu, Yifang, Yang, Yeon Suk, Eiseman, Mark, Shim, Jae-Hyuck, Hameed, Meera, Healey, John H., Bos

Journal:

Year:

2018

Language:

english

File:

PDF, 70.41 MB

english, 2018

21

Osteoimmunology: A Brief Introduction

Greenblatt, Matthew B., Shim, Jae-Hyuck

Journal:

Year:

2013

Language:

english

File:

PDF, 796 KB

english, 2013

22

The ERK MAPK Pathway Is Essential for Skeletal Development and Homeostasis

Kim, Jung-Min, Yang, Yeon-Suk, Park, Kwang Hwan, Oh, Hwanhee, Greenblatt, Matthew B., Shim, Jae-Hyuck

Journal:

International Journal of Molecular Sciences

Year:

2019

Language:

english

File:

PDF, 3.99 MB

english, 2019

23

The ERK MAPK Pathway Is Essential for Skeletal Development and Homeostasis

Kim, Jung-Min, Yang, Yeon-Suk, Park, Kwang Hwan, Oh, Hwanhee, Greenblatt, Matthew B., Shim, Jae-Hyuck

Journal:

International Journal of Molecular Sciences

Year:

2019

File:

PDF, 3.99 MB

2019

24

Bone-targeting AAV-mediated silencing of Schnurri-3 prevents bone loss in osteoporosis

Yang, Yeon-Suk, Xie, Jun, Wang, Dan, Kim, Jung-Min, Tai, Phillip W. L., Gravallese, Ellen, Gao, Guangping, Shim, Jae-Hyuck

Journal:

Nature Communications

Year:

2019

Language:

english

File:

PDF, 3.47 MB

english, 2019

25

The p38 MAPK pathway is essential for skeletogenesis and bone homeostasis in mice

Greenblatt, Matthew B., Shim, Jae-Hyuck, Zou, Weiguo, Sitara, Despina, Schweitzer, Michelle, Hu, Dorothy, Lotinun, Sutada, Sano, Yasuyo, Baron, Roland, Park, Jin Mo, Arthur, Simon, Xie, Min, Schneider

Journal:

Journal of Clinical Investigation

Year:

2010

Language:

english

File:

PDF, 6.92 MB

english, 2010

26

CRBN Is a Negative Regulator of Bactericidal Activity and Autophagy Activation Through Inhibiting the Ubiquitination of ECSIT and BECN1

Kim, Mi-Jeong, Min, Yoon, Shim, Jae-Hyuck, Chun, Eunyoung, Lee, Ki-Young

Journal:

Frontiers in Immunology

Year:

2019

Language:

english

File:

PDF, 13.39 MB

english, 2019

27

Bone-Targeting AAV-Mediated Gene Silencing in Osteoclasts for Osteoporosis Therapy

Yang, Yeon-Suk, Xie, Jun, Chaugule, Sachin, Wang, Dan, Kim, Jung-Min, Kim, JiHea, Tai, Phillip W.L., Seo, Seok-kyo, Gravallese, Ellen, Gao, Guangping, Shim, Jae-Hyuck

Journal:

Molecular Therapy — Methods & Clinical Development

Year:

2020

File:

PDF, 4.81 MB

2020

28

Osteoblast-Osteoclast Communication and Bone Homeostasis

Kim, Jung-Min, Lin, Chujiao, Stavre, Zheni, Greenblatt, Matthew B., Shim, Jae-Hyuck

Journal:

Year:

2020

File:

PDF, 835 KB

2020

29

TAOK3 is a MAP3K contributing to osteoblast differentiation and skeletal mineralization

Li, Zan, Oh, Hwanhee, Cung, Michelle, Marquez, Sofia Jenia, Sun, Jun, Hammad, Hamida, Janssens, Sophie, Pouliot, Philippe, Lambrecht, Bart N., Yang, Yeon-Suk, Shim, Jae-Hyuck, Greenblatt, Matthew B.

Journal:

Biochemical and Biophysical Research Communications

Year:

2020

File:

PDF, 1.28 MB

2020

30

MEKK2 mediates aberrant ERK activation in neurofibromatosis type I

Bok, Seoyeon, Shin, Dong Yeon, Yallowitz, Alisha R., Eiseman, Mark, Cung, Michelle, Xu, Ren, Li, Na, Sun, Jun, Williams, Alfred L., Scott, John E., Su, Bing, Shim, Jae-Hyuck, Greenblatt, Matthew B.

Journal:

Nature Communications

Year:

2020

File:

PDF, 3.21 MB

2020